Bio-X

Researchers create first functional stem cell niche

Weissman.jpgLike it or not, your living room says a lot about you. Given a few moments to poke around, a stranger could get a good idea of your likes and dislikes, and maybe even your future plans. Medical school scientists, employing a similar "peeping Tom" tactic to learn more about how stem cells develop, have taken a significant step forward by devising a way to re­create the cells' lair—a microenvironment called a niche—in an animal.

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Mysterious snippets of DNA withstand eons of evolution, computer analysis shows

double-helix.jpgSmall stretches of seemingly useless DNA harbor a big secret. There’s one problem: We don’t know what it is. Although individual laboratory animals appear to live happily when these genetic ciphers are deleted, these snippets have been highly conserved throughout evolution, suggesting that they have some value.

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Scientists identify new kind of stem cell found in testes

Reijo-Pera.jpgScientists at the School of Medicine and at UCSF have succeeded in isolating stem cells from human testes. The cells bear a striking resemblance to embryonic stem cells—they can differentiate into each of the three main types of body tissue—but the researchers caution against viewing them as one and the same.

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Study sheds light on key trigger of stem cell differentiation

Nusse.jpgClusters of mouse embryonic stem cells called embryoid bodies more closely approximate true embryos in organization and structure than previously thought, according to researchers at the School of Medicine. Harnessing the signals that influence the cells' fate may help researchers more accurately direct the differentiation of embryonic stem cells for use in therapy.

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Bio-X researchers take first look at working muscle fiber with needle-thin probe

muscle_two.jpgUsing a tiny scope and laser light Bio-X researchers including BioE and ME Professor Scott Delp have found a new way to study how muscle works, which could aid in treatment of muscle disesases such as cerebral palsy.

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Getting the Feel of Surgery

main_image-surgerysim.jpgHow can medical students practice surgery without placing patients at risk? Stanford surgeons and computer scientists are working together to create a hands-on surgical simulator with an incredibly realistic sense of touch.

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Microfluidic technology leads researchers to drug that could treat hepatitis C

microfuidicTech.jpgThe fight against the liver disease hepatitis C has been at something of an impasse for years, with more than 150 million people currently infected, and traditional antiviral treatments causing nasty side effects and often falling short of a cure. Using a novel technique, medical and engineering researchers at Stanford have discovered a vulnerable step in the virus' reproduction process that in lab testing could be effectively targeted with an obsolete antihistamine.

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Detecting and treating disease, one molecule at a time

main_image-Gambhir.jpgAccording to Sanjiv "Sam" Gambhir, molecular imaging is not so very different from good detective work. Just as detectives use a range of creative methods to find out what's going on behind the scenes, so do his "molecular detectives," as he calls them.

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Caller ID in the wild: African elephants communicate by ground vibration

main_image-elephant.jpgIn the vast expanse of African grasslands, wild herds of migrating elephants have learned to communicate with each other by listening with their feet to vibrations in the ground. Now a Stanford University School of Medicine researcher has found their seismic communication system is so sophisticated the elephants have their own version of "caller ID."

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Quantifying the body

main_image-simbios.jpgStanford professors are bringing quantitative and life sciences together; using physical and mathematical modeling to create computerized simulations of biological structures and functions. The hope is that this will ultimately enable doctors to make better diagnoses and treatment plans.

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